Yes, you can!
I'll comment some more when I'll receive my second gen II pro board to replace the gen I.
I usually connect an Emu E4XTUltra sampler through ADAT, a TC Konnekt through ADAT, a NL2x Rack synth, a Bass Station synth, an An1x synth, a Juno106 synth, some fx racks (3), a Kawai K5000 synth, and an MC808 with a A16 Ultra via ZLink, Till now, I'm only limited because of this gen I board I think.
I definitively agree with the fact it's just the central point for treatment and mixing of soft and hard.
How lucky we are
