As a Creamware/REAPER user and one who requested this features some time ago, I want to announce that version 1.806 just got a plug-in called ReaInsert which lets you send and return audio via user set ASIO-channels.
It also reports a user or auto set latency back to the host for easy latency compensation.
REAPER has a 64-bit floating point pipe-line/mixer and thus makes a great friend to our Creamware hardware.
Inserting effects is now a breeze

Also, REAPER is basically donation ware.